Two-time Emmy Award-winner Megan Mullally, coming off eight seasons as wisecracking socialite Karen Walker on NBC's "Will & Grace," moves into the driver's seat as host for this daytime talk show. Each episode is an entertaining hour featuring a mix of celebrities, real people, music, and comedy. Megan will interview top celebrities and also introduce the world to guests of all kinds — from quirky characters to funny kids to offbeat experts.
E1: Will Ferrell, Jenny McCarthy▶ PLAY
E2: Eva Mendes, "So You Think You Can Dance", Granny Basketball▶ PLAY
E3: Lisa Kudrow, 10 year-old Opera Singer, Adam Rodriguez▶ PLAY
E4: Carol Burnett, Rainn Wilson, Hollerin' Championships▶ PLAY
E5: Felicity Huffman, 'Animal Guys' Paul Hahn and David Riherd, Enrique Murciano▶ PLAY
E6: Julia Louis-Dreyfus, Illusionist Criss Angel, Mario Lopez▶ PLAY
E7: Debra Messing, Fashion Makeover with Lucky Magazine, Omar Epps▶ PLAY
E8: George Lopez, Jennifer Finnigan, Vacuum Cleaning Genius, Tim Bagley At A Cher Convention▶ PLAY
E9: Sela Ward, Chris Noth▶ PLAY
E10: Patricia Heaton, Duane Martin, Jesse McCartney▶ PLAY
E11: Jane Kaczmarek, Masi Oka, Champion Cloggers▶ PLAY
E12: Tom Bergeron, Eric Stromer, Elizabeth Perkins▶ PLAY
E13: Tim Daly, Domino Magazine▶ PLAY
E14: Connie Britton, Michael Clark Duncan▶ PLAY
E15: Jennifer Love Hewiitt, Jonny Lee Miller, J. Xavier▶ PLAY
E16: Virginia Madsen, Noah Gray-Cabey, Around The Office▶ PLAY
E17: Marcia Cross, Clinton Kelly, Isaiah Washington▶ PLAY
E18: Molly Ringwald, OK Go▶ PLAY
E19: Wanda Sykes, Goran Visnjic, Ruben Studdard▶ PLAY
E20: Peter Gallagher, Nathan Burton, Tyler James Williams▶ PLAY
E21: Bradley Whitford, Shelley Morrison, Eric Mabius, Mario Vazquez, Phil Pfister▶ PLAY
E22: Cheyenne Kimball, Laura Linney, Ricardo Antonio Chavira▶ PLAY
E23: Merv Griffin, Kim Raver, Author Jennifer Egan▶ PLAY
E24: Rob Morrow, Rebecca Cole, Anne Heche, Joshua Bell▶ PLAY
E25: Josh Duhamel, Alison Lohman, Authors Mark Leyner and Billy Goldberg, Aly & AJ Michalka▶ PLAY
E26: Kristin Chenoweth, Jill Conner Browne, Nick & Aaron Carter, the Sweet Potato Queens▶ PLAY
E27: Jamie Lee Curtis, The Mystic Pixies, Amy Smart, Taylor Swift▶ PLAY
E28: Lauren Holly, Ruben Studdard, Daniel Dae Kim▶ PLAY
E29: Cloris Leachman, Jensen Ackles, Dog Halloween Costumes with Teri Austin, ecostylist Danny Seo▶ PLAY
E30: James Denton, Yahoo 9's Maria Sansone, Angela Kinsey, JoJo▶ PLAY
E31: Steven Weber, Audra McDonald▶ PLAY
E32: Neil Patrick Harris, Kevin Federline▶ PLAY
E33: Jamie Kennedy, Jeffrey Sebelia, Meat Loaf, Card Thrower Rick Smith▶ PLAY
E34: Clay Aiken, Tysonia Tschinga "Real Life" Dancing with the Stars▶ PLAY
E35: Sean Hayes, Eddie Cibrian, Dog Whisperer Cesar Millan, Author Mitch Albom▶ PLAY
E36: Barry Manilow, Parminder Nagra, Tim Bagley visits "America's Got Talent", Kid's Ballroom Dancing▶ PLAY
E37: Mark Harmon, Hip Hop Champions, Constance Zimmer, Melora Hardin▶ PLAY
E38: Kevin Nealon, Antonio Sabato Jr.▶ PLAY
E39: Bob Saget, sex educator Sue Johanson▶ PLAY
E40: Molly Sims, Andrea Bowen, The Ten Tenors, Celebrity trainer Michael Carson▶ PLAY
E41: Cheryl Hines, Tim Gunn, Thanksgiving Dog Adoption Fashion Show▶ PLAY
E42: David Hyde Pierce, Linda Cardellini, Taylor Ware▶ PLAY
E43: Patricia Arquette, Champion Pirouette Dancer, Daily Candy Trends▶ PLAY
E44: Dax Shepard, Tom Arnold, Kimberley Locke▶ PLAY
E45: Reba McEntire, Patrick Wilson, RBD▶ PLAY
E46: Tom Bergeron, Trista and Ryan, Benji Schwimmer, Rupert Boneham▶ PLAY
E47: Sharon Stone, Scott Foley, Rusty Schwimmer, Paz Vega, Danny Seo▶ PLAY
E48: Wayne Brady, Penguins Pete and Penny, Nestle Toll House Bake Sale Finalist▶ PLAY
E49: Camryn Manheim, Phil Pfister, James Lesure, Author Karen Rizzo▶ PLAY
E50: Neil Patrick Harris, Josh Radnor, Alyson Hannigan, Jason Segel and Cobie Smulders▶ PLAY
E51: David Boreanaz, Julianne Nicholson, Bianca Ryan▶ PLAY
E52: Matthew Broderick, Donald Faison, Brian Baumgartner, the Bucket Boys, Catherine Lloyd Burns▶ PLAY
E53: Tracy Morgan, Melissa Peterman, Jarod Miller, Eric Stromer▶ PLAY
E54: Carrie Fisher, Paul Rodriguez, Nadine Velazquez▶ PLAY
E55: Rosanna Arquette, Tom Green, Adrian Pasdar▶ PLAY
E56: Marla Sokoloff, Taylor Hicks, "Campus Ladies"▶ PLAY
E57: Phyllis Diller▶ PLAY
E58: Carson Kressley, Beau Bridges, Amy Sedaris▶ PLAY
E59: Wendie Malick, Janice Dickinson▶ PLAY
E60: John Stamos, Brenda Strong, Cris Judd, Tyrese▶ PLAY
E61: David James Elliott, Michael Ealy, Lisa Edelstein, magician Nathan Burton▶ PLAY
E62: Jeffrey Tambor, Tisha Campbell, designer Mark Montano, Hall & Oates▶ PLAY
E63: Shawn and Marlon Wayans, Taylor Hicks▶ PLAY
E64: Oded Fehr, Rob Morrow, Rhea Perlman, Sarah Rush▶ PLAY
E65: Howie Mandel, Jennie Garth, Ahmet Zappa, psychic medium Lisa Williams▶ PLAY
E66: Jane Seymour, David Conrad, Ken Davitian, Joshua Radin▶ PLAY
E67: Alfre Woodard, Milo Ventimiglia, Fantasia Barrino▶ PLAY
E68: Billy Ray Cyrus, Richard Simmons, authors of "Party Confidential"▶ PLAY
E69: Hall & Oates, Brian McKnight, Clay Aiken, José Feliciano, Kimberley Locke, Celtic Woman▶ PLAY
E70: Emily Procter, Tichina Arnold, Goo Goo Dolls▶ PLAY
E71: Natalie Cole, Craig Bierko, Dave Annable, Blaine Zuckerman▶ PLAY
E72: Tom Bergeron, Tim Daly, Will Ferrell, Allison Janney, Davy Jones, Chris Noth, Jerry Springer▶ PLAY
E73: Patricia Heaton, Cheryl Hines, Debra Messing, Christine Taylor▶ PLAY
E74: Josh Duhamel, Jamie Kennedy, George Lopez, Mario Lopez▶ PLAY
E75: Selma Blair, Kristin Chenoweth, Lisa Kudrow, Laura Linney, Julia Louis-Dreyfus▶ PLAY
E76: Chandra Wilson, Jesse Bradford, Clay Aiken▶ PLAY
